Cloud-Based Clinical Research Software
This case study explores how Closeloop designed and delivered Vestigo — a fully custom, cloud-based platform for the McCreadie Group — empowering Investigational Drug Services to manage protocol budgets, checklists, drug tracking, and clinical trial workflows in one seamlessly integrated solution.
The McCreadie Group provides a cutting-edge software solution called Vestigo for Investigational Drug Services (IDS). Vestigo stands as a web-based platform utilized by Investigational Drug Services to effectively oversee investigational drug products.
This comprehensive platform facilitates the tracking of both significant and intricate details, encompassing trial statuses, study teams, patient enrollments, IRB expirations, and more.
Vestigo seamlessly interfaces with OnCore, Research Pharmacists, EMR Systems, and Clinical Trial Management Systems (CTMS), making it the go-to platform for clinical trial management.
Operational Gaps in Protocol Management
Upon thorough analysis of the current process, business requirements, and workflow within Vestigo, it became evident that certain features, flows, and business aspects needed enhancement to ensure heightened security and transparency within the system.
Manual Budget Creation
The Investigational Pharmacy relied on Excel to compile fees based on study phase, drug preparation, storage, and administration — demanding significant time to create, manage, and keep files updated.
No Active Study Linkage
There was no mechanism to link the study once it became active, impeding monitoring of provided costs against the actual expenses incurred during the trial lifecycle.
Fragmented Protocol Checklists
Sites resorted to disparate Excel or Word solutions to track and allocate tasks pertaining to protocol development — an unwieldy method that failed to integrate with Vestigo's broader solution.
Inconsistent Workflows
Tasks such as budgeting, Site Qualification, drug builds in EMR systems, and Vestigo build verification lacked a unified and standardized tracking mechanism across sites.
Security & Transparency Gaps
The existing process lacked the security controls and visibility required to manage investigational drug products at the level expected by regulatory and institutional standards.
Integrated Clinical Workflow Automation
Closeloop addressed the core operational challenges by delivering two tightly integrated solutions within the Vestigo platform — Protocol Budget and Protocol Checklist — each designed to standardize, automate, and bring transparency to the clinical trial workflow.
Protocol Budget
Provided the Investigational Pharmacy with an electronic solution within Vestigo to build consistent and repeatable budget templates. Pharmacy teams can now use these templates when creating protocols, eliminating the need to reconfigure fees each time a new budget is approved.
- Reusable budget templates for studies
- Reliable repository of all budgets
- Visibility into quantity and fee structures
- Linked to active protocols for cost monitoring
Protocol Checklist
Implemented a Protocol Checklist that leverages templates to provide a consistent method of managing and reporting on the status of protocol tasks — from Site Qualification and budgeting (pre-approval) to drug builds in EMR and Vestigo build verification (while live).
- Template-driven, standardized checklists
- Common practice across sites and facilities
- Assign users and set due dates per task
- Automated alerts for overdue checklist items
Development & Solution Architecture
Closeloop designed, developed, deployed, and maintained the McCreadie Group's Vestigo software — a fully custom software platform for supporting all aspects of Vestigo's business. Vestigo is integrated with 3rd party vendors and includes a full set of APIs for external partners to connect.
Designed and built an intuitive user interface tailored to pharmacy and clinical trial workflows.
Architected a scalable, modular system capable of supporting multiple integrations and future expansions.
Seamless integration with OnCore, EMR Systems, and Clinical Trial Management Systems (CTMS).
Rigorous QA testing, user acceptance testing, and staff training prior to final deployment.
Platform Capabilities
- Full-cycle protocol management from initiation to closure
- IRB expiration tracking and renewal alerts
- Patient enrollment and study team management
- Investigational drug product inventory oversight
- Budget templating and cost reconciliation
- API suite for external partner connectivity
Technical Architecture
Tech Stack
ASP.Net
VB .Net
Database SQL
JavaScript
BackBone JS
Business Impact and Results
Closeloop developed and delivered two-factor authentication and an automated removal process, transforming the way the McCreadie Group's platform handles security and program administration.
Approximately a 45% reduction in daily support tickets related to password resets.
Improved capability for Residency Program Directors (RPD) to manage programs effectively.
Streamlined password recovery process for residents, enhancing overall user satisfaction and security measures.
Explore the complete journey from problem to results—backed by real data and insights.
Client Value & Feedback
Client feedback reflects not just satisfaction with technical execution, but appreciation for the strategic partnership and business outcomes achieved.
"Closeloop designed, developed, deployed, and maintained our Vestigo software — a fully custom platform for supporting all aspects of our business. The platform was conceptualized and delivered within 4–5 months, including frontend UI, solution architecture, coding, QA, training, and final deployment. Their team truly understood our clinical research workflows and translated them into a system that works."
— McCreadie Group, Vestigo Product Team